Researcher or Postdoctoral Fellow in organoids and organs-on-chip W/M

Employeur

The university of Bordeaux is a great dynamic and responsible university that cares about the well-being of its staff. Joining us means working in a privileged environment within a particularly diverse and open professional community, benefiting from welcome and inclusion schemes, training and internal mobility. It means participating in an academic, scientific and human adventure. It means committing to meeting the challenges of the 21st century.

Join the Cardio-Thoracic Research Center of Bordeaux (CRCTB)! This research unit, composed of 3 teams, aims to combine clinical and basic research to advance the understanding and treatment of cardiothoracic diseases by promoting collaboration between scientists, clinicians and industrial partners. 

As part of the MICROCOSM research project, included in the Priority Research Equipment and Program (PEPR) Organs and Organoids on a Chip (MED-OoC), we are recruiting a Researcher or Postdoctoral Fellow in organoids and organs-on-chip W/M.

Our project aims to develop a multi-organ-chip platform to predict COPD patient responses to biologics and choose the most effective biologics.

Votre mission

You will be involved in the development of the multi-organ platform integrating lung (bronchial and alveolar) and muscle cells to reproduce the pathophysiology of COPD.

You will notably interact with our partners (F. Mallogi, K. Perez-Torralla, CEA Saclay) for the development of the microfluidic chip, work on the integration of primary patient cells and on the validation of the device based on biological criteria.

Finally, the device will be used to test the response of patient cells to biotherapies. This response can be linked to the clinical data of patients followed at the CHU de Bordeaux. You will also participate in the project coordination. 

During the mission you will be led to practice:

•       Culture of primary lung cells and/or skeletal muscle, in 2D and within a microfluidic device

•       Functional measurements: transepithelial resistance, muscle contraction

•       Inflammation level measurements: RT-qPCR, ELISA, bioplex

•       Immunocytochemistry, imaging and 3D reconstruction

•       Flow cyrtometry

•       Single-cell transcriptomic 

The + of this position: you will be integrated into the "COPD" group of the Bronchial Remodeling team. This group focused on the physiopathology of COPD is a young and dynamic team of about 10 people, led by Isabelle Dupin. We have recognized expertise in pulmonary physiology and pathophysiology and develop 3D in vitro models based on innovative cell culture and imaging techniques.

Vos atouts / Vos talents

Holder of a PhD in Cell Biology, Physio-pathology or Bio-engineering, you have significant experience in the field of organs on chips or 3D models at least, a solid scientific profile attested by a good level of publications.

•       You are open-minded

•       You demonstrate a sense of communication to work in interdisciplinarity

•       You master primary cell culture, ideally on lung and/or skeletal muscle

•       Knowledge of "omics" imaging and analysis techniques is appreciated

•       You are proficient in oral and written English (C1 level) in a multicultural work context

Do you recognize yourself? Apply!

More information:

Based in Pessac, Gironde, FRANCE – access by tramway line b (stop « France Alouette ») buses, bike, at the heart of the university hospital campus specialized in cardio-thoracic pathology.

This position is located in an area covered by the protection of scientific and technical potential (PPST) and therefore requires, in accordance with the regulations, that your arrival be authorised by the competent authority of the Ministry.

36-month fixed-term contract

Gross monthly salary: from 2750€ to 5500€ according to experience and salary grid

What we offer:

A training course adapted to support your job taking-up and your professional development

Up to 50 days of annual leave from the first year (in proportion to the arrival date)

Remote work possible depending on the organization of the service

Participation in complementary social protection and access to social action mechanisms

75% coverage of the public transport subscription in Gironde

Sustainable mobility package for home trips–work

Access to a staff parking

Leisure, sport and culture offers for all staff

Recruitment process: Applications are reviewed as they arrive.

Candidates selected for an interview will be contacted by the Recruitment Officer for a first pre-qualification phone conversation. An interview with the supervisor will then be organised by videoconference.

Interested applicants should send a CV, brief statement of qualifications and basis for interest in the position, a list of your relevant publications, and the email addresses of 2 appropriate references.