20 new laureates for the 2025 "Interdisciplinary and Exploratory Research" call

Description:

AI-assisted development of new ultra-short antimicrobial peptides to combat antibiotic resistance observed in oral diseases and study of mechanisms of action.

Coordination:

• Émilie Genin, Professor at the University of Bordeaux - Institute of Molecular Sciences (ISM, Bordeaux INP unit, CNRS and University of Bordeaux)
  Material and light sciences department
• Akka Zemmari, Professor at the University of Bordeaux - Bordeaux Computer Science Research Laboratory (LABRI, Bordeaux INP unit, CNRS and University of Bordeaux)
  Engineering and digital sciences department
• Johan Samot, Associate professor and hospital practitioner at the University of Bordeaux and Bordeaux University Hospital - Oenology Laboratory (OENO - Bordeaux INP, BSA, INRAE and University of Bordeaux unit)
  Environmental sciences department

Description:

Analysing psychosocial factors of vulnerability and resilience, while identifying objective biomarkers of vicarious trauma and/or burnout, in order to better protect populations exposed to the suffering of others, such as healthcare professionals, law enforcement officers, firefighters and family carers.

Coordination:

• Anouck Amestoy, 

  Professor and hospital practitioner (PUPH) at the University of Bordeaux and the Charles Perrens Specialised Hospital Centre - Aquitaine Institute of Cognitive and Integrative Neurosciences (INCIA, CNRS unit and University of Bordeaux)
  Bordeaux Neurocampus

• Bruno Quintard,

  Professor at the University of Bordeaux - Psychology Laboratory (LabPsy, University of Bordeaux unit)
  Behaviour, organisations and policy evaluation department

Description:

Observing and modelling the influence of compaction pressure on the microstructure and ion transport properties of different solid electrolytes used in all-solid-state batteries

Coordination:

• Lucas Lapostolle, Associate professor at Bordeaux INP - (I2M, Arts et Métiers ParisTech, Bordeaux INP, CNRS and University of Bordeaux)
  Engineering and digital sciences department
• Rafael Bianchini-Nuernberg, 

  Associate professor at Bordeaux INP - Bordeaux Institute of Condensed Matter Chemistry (ICMCB - CNRS unit and University of Bordeaux)
  Material and light sciences department

Description:

The project aims to study the content of archaeological ceramics discovered in a Gallic temple using environmentally friendly and non-invasive supercritical fluid extraction methods coupled with mass spectrometry.

Coordination:

• Samuel Marre, CNRS Research Director - Bordeaux Institute of Condensed Matter Chemistry (ICMCB - CNRS unit and University of Bordeaux)

  Materials and lights sciences department

• Isabelle Pianet, CNRS research engineer - Archéosciences Bordeaux: materials, images, societies (CNRS unit and Bordeaux Montaigne University)

  Archaeological sciences department

Description:

Deciphering the key biophysical and biochemical parameters necessary for the design of biomimetic helical and motile artificial cells, a major challenge in synthetic biology, by drawing inspiration from the molecular mechanisms of motile helical bacteria without cell walls.

Coordination:

• Laure Beven, Professor at the University of Bordeaux - Fruit Biology and Pathogenicity (BFP, INRAE unit and University of Bordeaux)
  Environmental sciences department
• Birgit Habenstein,

  CNRS Research Fellow - Institute of Chemistry and Biology of Membranes and Nano-Objects (CBMN, Bordeaux INP, CNRS and University of Bordeaux unit)
  Health sciences and technologies department

Description:

Combining four disciplines to conceptualise a constantly changing object, the personal learning environment, particularly in a context of increasing numbers of distance learners. Proposing tools that support the development of learning strategies adapted to distance learners.

Coordination:

• Clément Dussarps, Associate professor at the University of Bordeaux - Laboratory for the Integration of Materials into Systems (IMS - Bordeaux INP, CNRS and University of Bordeaux unit)
  Engineering and digital sciences department
• Alice Le Coz, 

  Associate professor at the University of Bordeaux - Culture, Education and Society Laboratory (LACES, University of Bordeaux unit)
  Behaviour, organisations and policy evaluation department

Description:

Thanks to very recent experimental advances, it is now possible to synthesise artificial materials or systems with flat bands in their energy spectrum. These flat bands provide unique platforms for exacerbating particle interactions and quantum geometry effects. Furthermore, they challenge the standard descriptions of transport developed for wide-band metals. The FLATBANDS project aims to establish a theory of quantum dynamics and transport in these flat-band systems by combining the expertise in mathematics and theoretical physics of two teams at the University of Bordeaux, rigorously treating the transition to the flat-band limit in models relevant to physics and possible future applications.

Coordination:

• Jérôme Cayssol, 

  Professor - Aquitaine Waves and Matter Laboratory (LOMA, CNRS unit and University of Bordeaux)
  Material and lights sciences department

• Vincent Bruneau, Professor - Bordeaux Institute of Mathematics (IMB, Bordeaux INP unit, CNRS and University of Bordeaux)
  Engineering and digital sciences department

Description:

Designing an automated, non-destructive method for analysing the contents of funerary urns using X-ray microtomography, artificial intelligence and computer vision

Coordination:

• Nicolas Vanderesse,

  CNRS Research Engineer - Laboratory of Prehistory to the Present: Culture, Environment and Anthropology (PACEA, unit of the Ministry of Culture, CNRS and University of Bordeaux)
  Archaeological sciences department

• Michaël Clément, 

  Associate professor at Bordeaux INP - Bordeaux Computer Science Research Laboratory (LaBRI, Bordeaux INP unit, CNRS and University of Bordeaux)
  Engineering and digital sciences department

Description:

The aim of the GlycoMécano project is to develop molecular tools capable of modulating the rigidity of the neural extracellular matrix (ECM) of neuronal tissue in order to study the effect of synaptic environment stiffening on plasticity.

Coordination:

• Frédéric Friscourt, Associate professor at the University of Bordeaux - Institute of Molecular Sciences (ISM, Bordeaux INP unit, CNRS and University of Bordeaux)
  Material and light sciences department
• Morgane Rosendale, CNRS Research Fellow - Interdisciplinary Institute of Neuroscience (IINS, CNRS unit and University of Bordeaux)
  Bordeaux Neurocampus

Description:

The scientific challenge addressed by LabW is to bring together part of the social sciences and humanities community at the University of Bordeaux and beyond around the theme of work, health and environmental transitions in order to structure ourselves to respond to an eminently complex and topical social issue. The focus will be on democratic issues and challenges posed through the prism of the subject of alert. In addition to improving knowledge, the work generated by LabW will encourage interdisciplinary collaboration and build bridges between the social sciences and public health, as well as between the academic and professional worlds. LabW will open up new avenues for collaboration and establish links with socio-economic actors and partnerships. Comparison is one of the key words for encouraging international research and publications through the comparison of systems, populations, social aspects and different solutions to these complex issues in our changing world.

Coordination:

• Loïc Lerouge, Research Director, CNRS - Centre for Comparative Labour and Social Security Law (COMPTRASEC, CNRS unit and University of Bordeaux)
  Law and social transformations department
• Guillaume Déprez, 

  Associate professor at the University of Bordeaux - Psychology Laboratory (LabPsy, University of Bordeaux unit)
  Behaviour, organisations and policy evaluation department

• Andy Smith, Research Director at the National Foundation for Political Science - Émile Durkheim Centre (CNRS unit, Sciences Po Bordeaux and University of Bordeaux)
  Social sciences of contemporary changes department

Description:

Living organisms are strongly affected by light. By applying pulsed laser light at very high frequencies, we aim to study the interaction between light and viruses, with the potential for innovative applications in human, animal and environmental health.

Coordination:

• Mathieu Métifiot, CNRS researcher – Fundamental Microbiology and Pathogenicity Laboratory (MFP, CNRS unit and University of Bordeaux)
  Biological and medical sciences department
• Denis Marion, Researcher at CEA - Centre for Intense Lasers and Applications (CELIA, CEA unit, CNRS and University of Bordeaux)
  Material and light sciences department

Description:

For decades, preclinical studies have mainly involved male animals, leading to the development of treatments designed primarily for men. These treatments do not take into account physiological differences between men and women, and may therefore be ineffective or even harmful to women. This project, based on a metabolic stress model, explores the biological mechanisms specific to females that are responsible for their resilience. This work could lead to the development of more effective and personalised treatments for diseases such as metabolic disorders associated with obesity.

Coordination:

• Agnès Nadjar, Professor at the University of Bordeaux - Neurocentre Magendie (Inserm unit and University of Bordeaux)
  Bordeaux Neurocampus
• Vanja Sisirak, CNRS Research Director – Conceptual, Experimental and Translational Immunology (Immunoconcept, CNRS unit, Inserm and University of Bordeaux)
  Biological and medical sciences department

Description:

Towards more accurate reconstructions of mammalian diets from skeletal remains

Coordination:

• Antoine Souron, Associate professor at the University of Bordeaux - Laboratory of Prehistory to the Present: Culture, Environment and Anthropology (PACEA, unit of the Ministry of Culture, CNRS and University of Bordeaux)
  Archaeological sciences department
• Pierre Pétriacq, Associate professor at the University of Bordeaux - Fruit Biology and Pathogenicity Laboratory (BFP, INRAE unit and University of Bordeaux)
  Environmental sciences department

Description:

Providing the university's scientific community with an original multi-omic and multimodal imaging method combining mass spectrometry and immunofluorescence, as well as innovative computer tools needed to extract relevant data, regardless of the biological or health issue at hand.

Coordination:

• Nicolas Desbenoit, CNRS Research Fellow - Institute of Chemistry and Biology of Membranes and Nano-Objects (CBMN, Bordeaux INP, CNRS and University of Bordeaux unit)

  Health sciences and technologies department

• Giovanni Bénard, CNRS Research Director – Rare Diseases: Genetics and Metabolism Laboratory (MRGM, Inserm unit and University of Bordeaux)
  Biological and medical sciences department

• Baudoin Denis de Senneville, CNRS Research Director - Bordeaux Mathematics Institute (IMB, Bordeaux INP unit, CNRS and University of Bordeaux)
  Engineering and digital sciences department

Description:

Study and improvement of water nucleation/harvesting cycles from air humidity on porous fibres made of nanotubes with dual hydrophobic/hydrophilic properties.

Coordination:

• Etienne Gaufrès, CNRS Research Fellow - Photonics, Digital and Nanosciences Laboratory (LP2N – CNRS unit, IOGS and University of Bordeaux)

  Material and light sciences department

• Philippe Poulin, Research Director, CNRS - Paul Pascal Research Centre (CRPP, CNRS unit and University of Bordeaux)
  Material and light sciences department
• Jonathan Daniel, CNRS research engineer - Institute of Molecular Sciences (ISM, Bordeaux INP unit, CNRS and University of Bordeaux)
  Material and light sciences department

Description:

The growing presence of gadolinium-based contrast agents (Gd-CAs) in aquatic ecosystems and drinking water poses major environmental and health challenges. The ONE HEALTH project aims to address these issues by defining the (eco-)toxicological effects and risks associated with the increasing exposure of aquatic ecosystems and humans to these emerging contaminants. To this end, four complementary and exploratory areas of research will be used to assess: the ecotoxicological effects of chronic exposure to Gd-CAs in young fish; the toxicological effects of chronic exposure to Gd-CAs in pregnant mice and their offspring;  the associated health and environmental risks and how law and public policy address or should address the issue of these emerging contaminants, in accordance with the fundamental right to a healthy environment and in approaches that combine the concepts of ‘Exposome’ and ‘One Health’.

Coordination:

• Clément Pereto, Research engineer at the University of Bordeaux - Oceanic and Continental Environments and Paleoenvironments Laboratory (EPOC, Bordeaux INP unit, CNRS and University of Bordeaux)
  Environmental sciences department
• Magalie Baudrimont, Professor at the University of Bordeaux - Oceanic and Continental Environments and Paleoenvironments Laboratory (EPOC, Bordeaux INP, CNRS and University of Bordeaux unit)
  Environmental sciences department
• Didier Morin, Professor at the University of Bordeaux - Aquitaine Institute of Cognitive and Integrative Neurosciences (INCIA, CNRS unit and University of Bordeaux)

  Bordeaux Neurocampus

• Marion Tissier-Raffin, Associate professor at the University of Bordeaux - Centre for European and International Research and Documentation (CRDEI, a unit of the University of Bordeaux)
  Law and social transformations department

Description:

This project aims to highlight the electrophysiological effects of autoantibodies found in the serum of patients suffering from severe arrhythmias associated with sudden cardiac death and to identify their targets. A longer-term objective is to improve the screening and stratification of patients at risk of sudden death and to offer them appropriate treatments.

Coordination:

• David Benoist, Associate professor at the University of Bordeaux - Bordeaux Cardiothoracic Research Centre (CRCTB, Inserm unit and University of Bordeaux)
  Health sciences and technologies department
• Cécile Bordes,

  Associate professor and Hospital Practitioner (MCU-PH) at the University of Bordeaux and Bordeaux University Hospital - Conceptual, Experimental and Translational Immunology (Immunoconcept, CNRS unit, Inserm and University of Bordeaux)
  Biological and medical sciences department

Description:

The aim of the PaléoPépins project is to overcome the scientific obstacles associated with the analysis of archaeobotanical remains in order to trace the origin and evolution of grape varieties in the Bordeaux region. It aims to develop innovative methodologies in morphometry, (palaeo)genomics and graph theory in order to better understand the history of viticulture and cultivation practices in the region.

Coordination:

• Pierre-François Bert, Associate professor at the University of Bordeaux - Laboratory of Ecophysiology and Functional Genomics of Vines (EGFV, Bordeaux Sciences Agro unit, INRAE and University of Bordeaux)
  Environmental sciences deparment
• Fanny Mendisco,

  CNRS Research Engineer - Laboratory of Prehistory to the Present: Culture, Environment and Anthropology (PACEA, Ministry of Culture, CNRS and University of Bordeaux unit)
  Archaeological sciences department

Description:

The SAGA project seeks to identify new avenues for prevention to preserve the mental health of the elderly population, which is particularly vulnerable. To this end, researchers wish to explore how a biological factor (age-related alteration of the gut microbiota) and a social factor (social isolation of the elderly) could have cumulative deleterious effects, leading to impaired mental health. Using a translational approach, they also want to characterise the mechanisms involved so that they can ultimately propose interventions targeting both biological and social factors.

Coordination:

• Quentin Leyrolle, Associate professor at the University of Bordeaux - Nutrition and Integrated Neurobiology Laboratory (NutriNeuro, Inserm unit and University of Bordeaux)
  Bordeaux Neurocampus
• Cécilia Samieri, Research Director, Inserm - Bordeaux Population Health Research Centre (BPH, Inserm unit and University of Bordeaux)
  Public health department

Description:

Develop glazing incorporating organic photovoltaic solar cells capable of automatically modulating their infrared transparency according to sunlight levels, so as to generate electricity and regulate heat flows entering buildings.

Coordination:

• Anthony Maho,

  Junior Professor Chair at the University of Bordeaux - Bordeaux Institute of Condensed Matter Chemistry (ICMCB - CNRS unit and University of Bordeaux)
  Material and lights sciences department

• Guillaume Wantz,

  Professor at Bordeaux INP - Laboratory for Material Integration into Systems (IMS – Bordeaux INP, CNRS and University of Bordeaux unit)
  Engineering and digital sciences department